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Structural mechanisms of CFTR function and dysfunction

Cystic fibrosis (CF) transmembrane conductance regulator (CFTR) chloride channel plays a critical role in regulating transepithelial movement of water and electrolyte in exocrine tissues. Malfunction of the channel because of mutations of the cftr gene results in CF, the most prevalent lethal geneti...

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Detalles Bibliográficos
Publicado en:J Gen Physiol
Autores principales: Hwang, Tzyh-Chang, Yeh, Jiunn-Tyng, Zhang, Jingyao, Yu, Ying-Chun, Yeh, Han-I, Destefano, Samantha
Formato: Artigo
Lenguaje:Inglês
Publicado: Rockefeller University Press 2018
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5881446/
https://ncbi.nlm.nih.gov/pubmed/29581173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201711946
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