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PRDM9 and its role in genetic recombination

PRDM9 is a zinc finger protein that binds DNA at specific locations in the genome where it trimethylates histone H3 at lysines 4 and 36 at surrounding nucleosomes. In meiosis in many species, including humans and mice where PRDM9 has been most intensely studied, these actions determine the location...

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Publicado en:Trends Genet
Autores principales: Paigen, Kenneth, Petkov, Petko M.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2018
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5878713/
https://ncbi.nlm.nih.gov/pubmed/29366606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tig.2017.12.017
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