Multimer Formation Explains Allelic Suppression of PRDM9 Recombination Hotspots

Genetic recombination during meiosis functions to increase genetic diversity, promotes elimination of deleterious alleles, and helps assure proper segregation of chromatids. Mammalian recombination events are concentrated at specialized sites, termed hotspots, whose locations are determined by PRDM9...

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Udgivet i:PLoS Genet
Main Authors: Baker, Christopher L., Petkova, Pavlina, Walker, Michael, Flachs, Petr, Mihola, Ondrej, Trachtulec, Zdenek, Petkov, Petko M., Paigen, Kenneth
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4569383/
https://ncbi.nlm.nih.gov/pubmed/26368021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005512
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