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PRDM9 binding organizes hotspot nucleosomes and limits Holliday junction migration
In mammals, genetic recombination during meiosis is limited to a set of 1- to 2-kb regions termed hotspots. Their locations are predominantly determined by the zinc finger protein PRDM9, which binds to DNA in hotspots and subsequently uses its SET domain to locally trimethylate histone H3 at lysine...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4009602/ https://ncbi.nlm.nih.gov/pubmed/24604780 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.170167.113 |
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