The Meiotic Recombination Activator PRDM9 Trimethylates Both H3K36 and H3K4 at Recombination Hotspots In Vivo

In many mammals, including humans and mice, the zinc finger histone methyltransferase PRDM9 performs the first step in meiotic recombination by specifying the locations of hotspots, the sites of genetic recombination. PRDM9 binds to DNA at hotspots through its zinc finger domain and activates recomb...

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Veröffentlicht in:PLoS Genet
Hauptverfasser: Powers, Natalie R., Parvanov, Emil D., Baker, Christopher L., Walker, Michael, Petkov, Petko M., Paigen, Kenneth
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2016
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4928815/
https://ncbi.nlm.nih.gov/pubmed/27362481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006146
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