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PRDM9 interactions with other proteins provide a link between recombination hotspots and the chromosomal axis in meiosis
In mammals, meiotic recombination occurs at 1- to 2-kb genomic regions termed hotspots, whose positions and activities are determined by PRDM9, a DNA-binding histone methyltransferase. We show that the KRAB domain of PRDM9 forms complexes with additional proteins to allow hotspots to proceed into th...
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| 出版年: | Mol Biol Cell |
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| 主要な著者: | , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
The American Society for Cell Biology
2017
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5341731/ https://ncbi.nlm.nih.gov/pubmed/27932493 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E16-09-0686 |
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