PRDM9 interactions with other proteins provide a link between recombination hotspots and the chromosomal axis in meiosis

In mammals, meiotic recombination occurs at 1- to 2-kb genomic regions termed hotspots, whose positions and activities are determined by PRDM9, a DNA-binding histone methyltransferase. We show that the KRAB domain of PRDM9 forms complexes with additional proteins to allow hotspots to proceed into th...

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Published in:Mol Biol Cell
Main Authors: Parvanov, Emil D., Tian, Hui, Billings, Timothy, Saxl, Ruth L., Spruce, Catrina, Aithal, Rakesh, Krejci, Lumir, Paigen, Kenneth, Petkov, Petko M.
Format: Artigo
Language:Inglês
Published: The American Society for Cell Biology 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5341731/
https://ncbi.nlm.nih.gov/pubmed/27932493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E16-09-0686
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