Pharmacokinetic Assessment of Cooperative Efflux of the Multitargeted Kinase Inhibitor Ponatinib Across the Blood-Brain Barrier

A compartmental blood-brain barrier (BBB) model describing drug transport across the BBB was implemented to evaluate the influence of efflux transporters on the rate and extent of the multikinase inhibitor ponatinib penetration across the BBB. In vivo pharmacokinetic studies in wild-type and transpo...

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Veröffentlicht in:J Pharmacol Exp Ther
Hauptverfasser: Laramy, Janice K., Kim, Minjee, Parrish, Karen E., Sarkaria, Jann N., Elmquist, William F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Pharmacology and Experimental Therapeutics 2018
Schlagworte:
Metabolism, Transport, and Pharmacogenomics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5878676/
https://ncbi.nlm.nih.gov/pubmed/29440450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.117.246116
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