Heterogeneous Binding and Central Nervous System Distribution of the Multitargeted Kinase Inhibitor Ponatinib Restrict Orthotopic Efficacy in a Patient-Derived Xenograft Model of Glioblastoma

This study investigated how differences in drug distribution and free fraction at different tumor and tissue sites influence the efficacy of the multikinase inhibitor ponatinib in a patient-derived xenograft model of glioblastoma (GBM). Efficacy studies in GBM6 flank (heterotopic) and intracranial (...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Pharmacol Exp Ther
Prif Awduron: Laramy, Janice K., Kim, Minjee, Gupta, Shiv K., Parrish, Karen E., Zhang, Shuangling, Bakken, Katrina K., Carlson, Brett L., Mladek, Ann C., Ma, Daniel J., Sarkaria, Jann N., Elmquist, William F.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The American Society for Pharmacology and Experimental Therapeutics 2017
Pynciau:
Drug Discovery and Translational Medicine
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5625285/
https://ncbi.nlm.nih.gov/pubmed/28847917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.117.243477
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