Heterogeneous Binding and Central Nervous System Distribution of the Multitargeted Kinase Inhibitor Ponatinib Restrict Orthotopic Efficacy in a Patient-Derived Xenograft Model of Glioblastoma

This study investigated how differences in drug distribution and free fraction at different tumor and tissue sites influence the efficacy of the multikinase inhibitor ponatinib in a patient-derived xenograft model of glioblastoma (GBM). Efficacy studies in GBM6 flank (heterotopic) and intracranial (...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:J Pharmacol Exp Ther
Hlavní autoři: Laramy, Janice K., Kim, Minjee, Gupta, Shiv K., Parrish, Karen E., Zhang, Shuangling, Bakken, Katrina K., Carlson, Brett L., Mladek, Ann C., Ma, Daniel J., Sarkaria, Jann N., Elmquist, William F.
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Pharmacology and Experimental Therapeutics 2017
Témata:
Drug Discovery and Translational Medicine
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5625285/
https://ncbi.nlm.nih.gov/pubmed/28847917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.117.243477
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky