SCDT-19. DELIVERY OF ISPINESIB IS LIMITED BY EFFLUX TRANSPORT AT THE BLOOD-BRAIN BARRIER (BBB)

PURPOSE: A challenge in developing therapies for GBM is the inability of drugs to cross the BBB. Ispinesib, an inhibitor of kinesin spindle protein, has potent anti-cancer activity by causing mitotic arrest and growth inhibition. The objective was to determine the distribution of ispinesib across th...

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Veröffentlicht in:Neuro Oncol
Hauptverfasser: Gampa, Gautham, Crish, James, Parrish, Karen, Cook-Rostie, Nicholas, Kim, Minjee, Laramy, Janice, Rosenfeld, Steven, Elmquist, William
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2017
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5692963/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.1102
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