Immunogenicity in Rabbits of HIV-1 SOSIP Trimers from Clades A, B, and C, Given Individually, Sequentially, or in Combination

Recombinant soluble HIV-1 envelope glycoprotein (Env) SOSIP trimers are a design platform for inducing broadly neutralizing antibodies (bNAbs) by vaccination. To date, these and alternative designs of native-like trimers, given singly or in pairs, have not induced bNAbs in test animals such as rabbi...

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Vydáno v:J Virol
Hlavní autoři: Torrents de la Peña, Alba, de Taeye, Steven W., Sliepen, Kwinten, LaBranche, Celia C., Burger, Judith A., Schermer, Edith E., Montefiori, David C., Moore, John P., Klasse, Per Johan, Sanders, Rogier W.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2018
Témata:
Vaccines and Antiviral Agents
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5874403/
https://ncbi.nlm.nih.gov/pubmed/29367243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01957-17
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