Immunogenicity in Rabbits of HIV-1 SOSIP Trimers from Clades A, B, and C, Given Individually, Sequentially, or in Combination

Recombinant soluble HIV-1 envelope glycoprotein (Env) SOSIP trimers are a design platform for inducing broadly neutralizing antibodies (bNAbs) by vaccination. To date, these and alternative designs of native-like trimers, given singly or in pairs, have not induced bNAbs in test animals such as rabbi...

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Détails bibliographiques
Publié dans:J Virol
Auteurs principaux: Torrents de la Peña, Alba, de Taeye, Steven W., Sliepen, Kwinten, LaBranche, Celia C., Burger, Judith A., Schermer, Edith E., Montefiori, David C., Moore, John P., Klasse, Per Johan, Sanders, Rogier W.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2018
Sujets:
Vaccines and Antiviral Agents
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5874403/
https://ncbi.nlm.nih.gov/pubmed/29367243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01957-17
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