A Statistical Thermodynamic Model for Ligands Interacting With Ion Channels: Theoretical Model and Experimental Validation of the KCNQ2 Channel

Ion channels are important therapeutic targets, and their pharmacology is becoming increasingly important. However, knowledge of the mechanism of interaction of the activators and ion channels is still limited due to the complexity of the mechanisms. A statistical thermodynamic model has been develo...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Front Pharmacol
Prif Awduron: Bai, Fang, Pi, Xiaoping, Li, Ping, Zhou, Pingzheng, Yang, Huaiyu, Wang, Xicheng, Li, Min, Gao, Zhaobing, Jiang, Hualiang
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Frontiers Media S.A. 2018
Pynciau:
Pharmacology
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5855359/
https://ncbi.nlm.nih.gov/pubmed/29593528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.00150
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