A Statistical Thermodynamic Model for Ligands Interacting With Ion Channels: Theoretical Model and Experimental Validation of the KCNQ2 Channel

Ion channels are important therapeutic targets, and their pharmacology is becoming increasingly important. However, knowledge of the mechanism of interaction of the activators and ion channels is still limited due to the complexity of the mechanisms. A statistical thermodynamic model has been develo...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Bai, Fang, Pi, Xiaoping, Li, Ping, Zhou, Pingzheng, Yang, Huaiyu, Wang, Xicheng, Li, Min, Gao, Zhaobing, Jiang, Hualiang
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5855359/
https://ncbi.nlm.nih.gov/pubmed/29593528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.00150
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