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Dynamic PIP(2) interactions with voltage sensor elements contribute to KCNQ2 channel gating
The S4 segment and the S4–S5 linker of voltage-gated potassium (Kv) channels are crucial for voltage sensing. Previous studies on the Shaker and Kv1.2 channels have shown that phosphatidylinositol-4,5-bisphosphate (PIP(2)) exerts opposing effects on Kv channels, up-regulating the current amplitude,...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3864334/ https://ncbi.nlm.nih.gov/pubmed/24277843 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1312483110 |
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