Dynamic PIP(2) interactions with voltage sensor elements contribute to KCNQ2 channel gating

The S4 segment and the S4–S5 linker of voltage-gated potassium (Kv) channels are crucial for voltage sensing. Previous studies on the Shaker and Kv1.2 channels have shown that phosphatidylinositol-4,5-bisphosphate (PIP(2)) exerts opposing effects on Kv channels, up-regulating the current amplitude,...

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Bibliografiske detaljer
Main Authors: Zhang, Qiansen, Zhou, Pingzheng, Chen, Zhuxi, Li, Min, Jiang, Hualiang, Gao, Zhaobing, Yang, Huaiyu
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2013
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3864334/
https://ncbi.nlm.nih.gov/pubmed/24277843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1312483110
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