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Molecular basis for ligand activation of the human KCNQ2 channel

The voltage-gated potassium channel KCNQ2 is responsible for M-current in neurons and is an important drug target to treat epilepsy, pain and several other diseases related to neuronal hyper-excitability. A list of synthetic compounds have been developed to directly activate KCNQ2, yet our knowledge...

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Podrobná bibliografie
Vydáno v:Cell Res
Hlavní autoři: Li, Xiaoxiao, Zhang, Qiansen, Guo, Peipei, Fu, Jie, Mei, Lianghe, Lv, Dashuai, Wang, Jiangqin, Lai, Dongwu, Ye, Sheng, Yang, Huaiyu, Guo, Jiangtao
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer Singapore 2020
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7852908/
https://ncbi.nlm.nih.gov/pubmed/32884139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41422-020-00410-8
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