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Working Model for the Structural Basis for KCNE1 Modulation of the KCNQ1 Potassium Channel
The voltage-gated potassium channel KCNQ1 (Kv7.1) is modulated by KCNE1 (minK) to generate the I(Ks) current critical to heartbeat. Defects in either protein result in serious cardiac arrhythmias. Recently-developed structural models of the open and closed state KCNQ1/KCNE1 complexes offer a compell...
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| Huvudupphovsmän: | , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
2011
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3070781/ https://ncbi.nlm.nih.gov/pubmed/21296569 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.sbi.2011.01.001 |
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