Allosteric mechanism for KCNE1 modulation of KCNQ1 potassium channel activation

The function of the voltage-gated KCNQ1 potassium channel is regulated by co-assembly with KCNE auxiliary subunits. KCNQ1-KCNE1 channels generate the slow delayed rectifier current, I(Ks), which contributes to the repolarization phase of the cardiac action potential. A three amino acid motif (F57-T5...

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Vydáno v:eLife
Hlavní autoři: Kuenze, Georg, Vanoye, Carlos G, Desai, Reshma R, Adusumilli, Sneha, Brewer, Kathryn R, Woods, Hope, McDonald, Eli F, Sanders, Charles R, George, Alfred L, Meiler, Jens
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2020
Témata:
Structural Biology and Molecular Biophysics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7584456/
https://ncbi.nlm.nih.gov/pubmed/33095155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.57680
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