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An Allosteric Mechanism for Drug Block of the Human Cardiac Potassium Channel KCNQ1
The intracellular aspect of the sixth transmembrane segment within the ion-permeating pore is a common binding site for many voltage-gated ion channel blockers. However, the exact site(s) at which drugs bind remain controversial. We used extensive site-directed mutagenesis coupled with molecular mod...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Pharmacology and Experimental Therapeutics
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3558809/ https://ncbi.nlm.nih.gov/pubmed/23193163 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.112.081513 |
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