Phosphatidylinositol 4,5-bisphosphate alters pharmacological selectivity for epilepsy-causing KCNQ potassium channels

Pharmacological augmentation of neuronal KCNQ muscarinic (M) currents by drugs such as retigabine (RTG) represents a first-in-class therapeutic to treat certain hyperexcitatory diseases by dampening neuronal firing. Whereas all five potassium channel subtypes (KCNQ1–KCNQ5) are found in the nervous s...

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Bibliographic Details
Main Authors: Zhou, Pingzheng, Yu, Haibo, Gu, Min, Nan, Fa-jun, Gao, Zhaobing, Li, Min
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2013
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3666695/
https://ncbi.nlm.nih.gov/pubmed/23650395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1302167110
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