Phosphatidylinositol 4,5-bisphosphate (PIP(2)) regulates KCNQ3 K(+) channels by interacting with four cytoplasmic channel domains

Phosphatidylinositol 4,5-bisphosphate (PIP(2)) in the plasma membrane regulates the function of many ion channels, including M-type (potassium voltage-gated channel subfamily Q member (KCNQ), K(v)7) K(+) channels; however, the molecular mechanisms involved remain unclear. To this end, we here focuse...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Main Authors: Choveau, Frank S., De la Rosa, Victor, Bierbower, Sonya M., Hernandez, Ciria C., Shapiro, Mark S.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Molecular Biophysics
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6302169/
https://ncbi.nlm.nih.gov/pubmed/30348901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.005401
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