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Phosphatidylinositol-4,5-bisphosphate is required for KCNQ1/KCNE1 channel function but not anterograde trafficking

The slow delayed-rectifier potassium current (I(Ks)) is crucial for human cardiac action potential repolarization. The formation of I(Ks) requires co-assembly of the KCNQ1 α-subunit and KCNE1 β-subunit, and mutations in either of these subunits can lead to hereditary long QT syndrome types 1 and 5,...

詳細記述

保存先:
書誌詳細
出版年:PLoS One
主要な著者: Royal, Alice A., Tinker, Andrew, Harmer, Stephen C.
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2017
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5636153/
https://ncbi.nlm.nih.gov/pubmed/29020060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0186293
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