KCNE1–KCNQ1 osmoregulation by interaction of phosphatidylinositol-4,5-bisphosphate with Mg(2+) and polyamines

KCNQ1 osmosensitivity is of physiological and pathophysiological relevance in epithelial and cardiac cells, but the mechanism involved remains elusive. In COS-7 cells expressing the KCNE1–KCNQ1 fusion protein, extracellular hypoosmolarity and hyperosmolarity modify the channel biophysical parameters...

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Detalhes bibliográficos
Main Authors: Piron, Julien, Choveau, Frank S, Amarouch, Mohammed Yassine, Rodriguez, Nicolas, Charpentier, Flavien, Mérot, Jean, Baró, Isabelle, Loussouarn, Gildas
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2010
Assuntos:
Cardiovascular
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2988512/
https://ncbi.nlm.nih.gov/pubmed/20660559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2010.195313
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