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KCNE1 enhances phosphatidylinositol 4,5-bisphosphate (PIP(2)) sensitivity of I(Ks) to modulate channel activity
Phosphatidylinositol 4,5-bisphosphate (PIP(2)) is necessary for the function of various ion channels. The potassium channel, I(Ks), is important for cardiac repolarization and requires PIP(2) to activate. Here we show that the auxiliary subunit of I(Ks), KCNE1, increases PIP(2) sensitivity 100-fold...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3107281/ https://ncbi.nlm.nih.gov/pubmed/21576493 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1100872108 |
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