Hydrogen sulfide inhibits Kir2 and Kir3 channels by decreasing sensitivity to the phospholipid phosphatidylinositol 4,5-bisphosphate (PIP(2))

Inwardly rectifying potassium (Kir) channels establish and regulate the resting membrane potential of excitable cells in the heart, brain, and other peripheral tissues. Phosphatidylinositol 4,5-bisphosphate (PIP(2)) is a key direct activator of ion channels, including Kir channels. The gasotransmitt...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Ha, Junghoon, Xu, Yu, Kawano, Takeharu, Hendon, Tyler, Baki, Lia, Garai, Sumanta, Papapetropoulos, Andreas, Thakur, Ganesh A., Plant, Leigh D., Logothetis, Diomedes E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5846148/
https://ncbi.nlm.nih.gov/pubmed/29317494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.001679
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