The Cytosolic GH Loop Regulates the Phosphatidylinositol 4,5-Bisphosphate-induced Gating Kinetics of Kir2 Channels

Inwardly rectifying K(+) (Kir) channels set the resting membrane potential and regulate cellular excitability. The activity of Kir channels depends critically on the phospholipid PIP(2). The molecular mechanism by which PIP(2) regulates Kir channel gating is poorly understood. Here, we utilized a co...

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Detalhes bibliográficos
Main Authors: An, Hai-Long, Lü, Shou-Qin, Li, Jun-Wei, Meng, Xuan-Yu, Zhan, Yong, Cui, Meng, Long, Mian, Zhang, Hai-Lin, Logothetis, Diomedes E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Molecular Biophysics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3516771/
https://ncbi.nlm.nih.gov/pubmed/23033482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.418640
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