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Structural Determinants of Phosphatidylinositol 4,5-Bisphosphate (PIP(2)) Regulation of BK Channel Activity through the RCK1 Ca(2+) Coordination Site
Big or high conductance potassium (BK) channels are activated by voltage and intracellular calcium (Ca(2+)). Phosphatidylinositol 4,5-bisphosphate (PIP(2)), a ubiquitous modulator of ion channel activity, has been reported to enhance Ca(2+)-driven gating of BK channels, but a molecular understanding...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4081927/ https://ncbi.nlm.nih.gov/pubmed/24778177 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.538033 |
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