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Structural Determinants of Phosphatidylinositol 4,5-Bisphosphate (PIP(2)) Regulation of BK Channel Activity through the RCK1 Ca(2+) Coordination Site

Big or high conductance potassium (BK) channels are activated by voltage and intracellular calcium (Ca(2+)). Phosphatidylinositol 4,5-bisphosphate (PIP(2)), a ubiquitous modulator of ion channel activity, has been reported to enhance Ca(2+)-driven gating of BK channels, but a molecular understanding...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Tang, Qiong-Yao, Zhang, Zhe, Meng, Xuan-Yu, Cui, Meng, Logothetis, Diomedes E.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: American Society for Biochemistry and Molecular Biology 2014
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4081927/
https://ncbi.nlm.nih.gov/pubmed/24778177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.538033
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