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Phosphatidylinositol 4,5-bisphosphate (PIP(2)) and Ca(2+) are both required to open the Cl(−) channel TMEM16A
Transmembrane member 16A (TMEM16A) is a widely expressed Ca(2+)-activated Cl(−) channel with various physiological functions ranging from mucosal secretion to regulating smooth muscle contraction. Understanding how TMEM16A controls these physiological processes and how its dysregulation may cause di...
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| Publicado no: | J Biol Chem |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6699839/ https://ncbi.nlm.nih.gov/pubmed/31266809 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.007128 |
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