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Phosphatidylinositol 4,5-bisphosphate (PIP(2)) and Ca(2+) are both required to open the Cl(−) channel TMEM16A

Transmembrane member 16A (TMEM16A) is a widely expressed Ca(2+)-activated Cl(−) channel with various physiological functions ranging from mucosal secretion to regulating smooth muscle contraction. Understanding how TMEM16A controls these physiological processes and how its dysregulation may cause di...

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Detaylı Bibliyografya
Yayımlandı:J Biol Chem
Asıl Yazarlar: Tembo, Maiwase, Wozniak, Katherine L., Bainbridge, Rachel E., Carlson, Anne E.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2019
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6699839/
https://ncbi.nlm.nih.gov/pubmed/31266809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.007128
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