KCNE1 enhances phosphatidylinositol 4,5-bisphosphate (PIP(2)) sensitivity of I(Ks) to modulate channel activity

Phosphatidylinositol 4,5-bisphosphate (PIP(2)) is necessary for the function of various ion channels. The potassium channel, I(Ks), is important for cardiac repolarization and requires PIP(2) to activate. Here we show that the auxiliary subunit of I(Ks), KCNE1, increases PIP(2) sensitivity 100-fold...

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Bibliographische Detailangaben
Hauptverfasser: Li, Yang, Zaydman, Mark A., Wu, Dick, Shi, Jingyi, Guan, Michael, Virgin-Downey, Brett, Cui, Jianmin
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2011
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3107281/
https://ncbi.nlm.nih.gov/pubmed/21576493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1100872108
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