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New Molecular Insight into Mechanism of Evolution of Mammalian Synthetic Prions

Previous studies established that transmissible prion diseases could be induced by in vitro-produced recombinant prion protein (PrP) fibrils with structures that are fundamentally different from that of authentic PrP scrapie isoform (PrP(Sc)). To explain evolution of synthetic prions, a new mechanis...

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Detalhes bibliográficos
Publicado no:Am J Pathol
Main Authors: Makarava, Natallia, Savtchenko, Regina, Alexeeva, Irina, Rohwer, Robert G., Baskakov, Ilia V.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5848243/
https://ncbi.nlm.nih.gov/pubmed/26873446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2015.11.013
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