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Stabilization of a Prion Strain of Synthetic Origin Requires Multiple Serial Passages

Transmission of prions to a new host is frequently accompanied by strain adaptation, a phenomenon that involves reduction of the incubation period, a change in neuropathological features and, sometimes, tissue tropism. Here we show that a strain of synthetic origin (SSLOW), although serially transmi...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Makarava, Natallia, Kovacs, Gabor G., Savtchenko, Regina, Alexeeva, Irina, Budka, Herbert, Rohwer, Robert G., Baskakov, Ilia V.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2012
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3436274/
https://ncbi.nlm.nih.gov/pubmed/22807452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.392985
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