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Stabilization of a Prion Strain of Synthetic Origin Requires Multiple Serial Passages
Transmission of prions to a new host is frequently accompanied by strain adaptation, a phenomenon that involves reduction of the incubation period, a change in neuropathological features and, sometimes, tissue tropism. Here we show that a strain of synthetic origin (SSLOW), although serially transmi...
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| Autores principales: | , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2012
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3436274/ https://ncbi.nlm.nih.gov/pubmed/22807452 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.392985 |
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