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A New Mechanism for Transmissible Prion Diseases
The transmissible agent of prion disease consists of prion protein (PrP) in β-sheet-rich state (PrP(Sc)) that can replicate its conformation according to a template-assisted mechanism. This mechanism postulates that the folding pattern of a newly recruited polypeptide accurately reproduces that of t...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Society for Neuroscience
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3368278/ https://ncbi.nlm.nih.gov/pubmed/22623680 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.6351-11.2012 |
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