A New Mechanism for Transmissible Prion Diseases

The transmissible agent of prion disease consists of prion protein (PrP) in β-sheet-rich state (PrP(Sc)) that can replicate its conformation according to a template-assisted mechanism. This mechanism postulates that the folding pattern of a newly recruited polypeptide accurately reproduces that of t...

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Bibliografski detalji
Glavni autori: Makarava, Natallia, Kovacs, Gabor G., Savtchenko, Regina, Alexeeva, Irina, Ostapchenko, Valeriy G., Budka, Herbert, Rohwer, Robert G., Baskakov, Ilia V.
Format: Artigo
Jezik:Inglês
Izdano: Society for Neuroscience 2012
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Articles
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3368278/
https://ncbi.nlm.nih.gov/pubmed/22623680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.6351-11.2012
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