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Genesis of Mammalian Prions: From Non-infectious Amyloid Fibrils to a Transmissible Prion Disease

The transmissible agent of prion disease consists of a prion protein in its abnormal, β-sheet rich state (PrP(Sc)), which is capable of replicating itself according to the template-assisted mechanism. This mechanism postulates that the folding pattern of a newly recruited polypeptide chain accuratel...

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Библиографические подробности
Главные авторы: Makarava, Natallia, Kovacs, Gabor G., Savtchenko, Regina, Alexeeva, Irina, Budka, Herbert, Rohwer, Robert G., Baskakov, Ilia V.
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2011
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3228811/
https://ncbi.nlm.nih.gov/pubmed/22144901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002419
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