Cohesin loss eliminates all loop domains

The human genome folds to create thousands of intervals, called “contact domains,” that exhibit enhanced contact frequency within themselves. “Loop domains” form because of tethering between two loci – almost always bound by CTCF and cohesin – lying on the same chromosome. “Compartment domains” form...

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Veröffentlicht in:Cell
Hauptverfasser: Rao, Suhas S. P., Huang, Su-Chen, St Hilaire, Brian Glenn, Engreitz, Jesse M., Perez, Elizabeth M., Kieffer-Kwon, Kyong-Rim, Sanborn, Adrian L., Johnstone, Sarah E., Bascom, Gavin D., Bochkov, Ivan D., Huang, Xingfan, Shamim, Muhammad S., Shin, Jaeweon, Turner, Douglass, Ye, Ziyi, Omer, Arina D., Robinson, James T., Schlick, Tamar, Bernstein, Bradley E., Casellas, Rafael, Lander, Eric S., Aiden, Erez Lieberman
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5846482/
https://ncbi.nlm.nih.gov/pubmed/28985562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2017.09.026
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