Cohesin loss eliminates all loop domains

The human genome folds to create thousands of intervals, called “contact domains,” that exhibit enhanced contact frequency within themselves. “Loop domains” form because of tethering between two loci – almost always bound by CTCF and cohesin – lying on the same chromosome. “Compartment domains” form...

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Publicado no:Cell
Main Authors: Rao, Suhas S. P., Huang, Su-Chen, St Hilaire, Brian Glenn, Engreitz, Jesse M., Perez, Elizabeth M., Kieffer-Kwon, Kyong-Rim, Sanborn, Adrian L., Johnstone, Sarah E., Bascom, Gavin D., Bochkov, Ivan D., Huang, Xingfan, Shamim, Muhammad S., Shin, Jaeweon, Turner, Douglass, Ye, Ziyi, Omer, Arina D., Robinson, James T., Schlick, Tamar, Bernstein, Bradley E., Casellas, Rafael, Lander, Eric S., Aiden, Erez Lieberman
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5846482/
https://ncbi.nlm.nih.gov/pubmed/28985562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2017.09.026
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