Mitochondrial tyrosyl‐DNA phosphodiesterase 2 and its TDP2(S) short isoform

Tyrosyl‐DNA phosphodiesterase 2 (TDP2) repairs abortive topoisomerase II cleavage complexes. Here, we identify a novel short isoform of TDP2 (TDP2(S)) expressed from an alternative transcription start site. TDP2(S) contains a mitochondrial targeting sequence, contributing to its enrichment in the mi...

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Bibliografske podrobnosti
izdano v:EMBO Rep
Main Authors: Huang, Shar‐yin N, Dalla Rosa, Ilaria, Michaels, Stephanie A, Tulumello, David V, Agama, Keli, Khiati, Salim, Jean, Sae Rin, Baechler, Simone A, Factor, Valentina M, Varma, Sudhir, Murai, Junko, Miller Jenkins, Lisa M, Kelley, Shana O, Pommier, Yves
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2018
Teme:
Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5836098/
https://ncbi.nlm.nih.gov/pubmed/29438979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201642139
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