Mitochondrial tyrosyl‐DNA phosphodiesterase 2 and its TDP2(S) short isoform

Tyrosyl‐DNA phosphodiesterase 2 (TDP2) repairs abortive topoisomerase II cleavage complexes. Here, we identify a novel short isoform of TDP2 (TDP2(S)) expressed from an alternative transcription start site. TDP2(S) contains a mitochondrial targeting sequence, contributing to its enrichment in the mi...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:EMBO Rep
Egile Nagusiak: Huang, Shar‐yin N, Dalla Rosa, Ilaria, Michaels, Stephanie A, Tulumello, David V, Agama, Keli, Khiati, Salim, Jean, Sae Rin, Baechler, Simone A, Factor, Valentina M, Varma, Sudhir, Murai, Junko, Miller Jenkins, Lisa M, Kelley, Shana O, Pommier, Yves
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: John Wiley and Sons Inc. 2018
Gaiak:
Articles
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5836098/
https://ncbi.nlm.nih.gov/pubmed/29438979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201642139
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