Mitochondrial tyrosyl‐DNA phosphodiesterase 2 and its TDP2(S) short isoform

Tyrosyl‐DNA phosphodiesterase 2 (TDP2) repairs abortive topoisomerase II cleavage complexes. Here, we identify a novel short isoform of TDP2 (TDP2(S)) expressed from an alternative transcription start site. TDP2(S) contains a mitochondrial targeting sequence, contributing to its enrichment in the mi...

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Detalhes bibliográficos
Publicado no:EMBO Rep
Main Authors: Huang, Shar‐yin N, Dalla Rosa, Ilaria, Michaels, Stephanie A, Tulumello, David V, Agama, Keli, Khiati, Salim, Jean, Sae Rin, Baechler, Simone A, Factor, Valentina M, Varma, Sudhir, Murai, Junko, Miller Jenkins, Lisa M, Kelley, Shana O, Pommier, Yves
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5836098/
https://ncbi.nlm.nih.gov/pubmed/29438979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201642139
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