Identifying Functional Hotspot Residues for Biased Ligand Design in G-Protein-Coupled Receptors

G-protein-coupled receptors (GPCRs) mediate multiple signaling pathways in the cell, depending on the agonist that activates the receptor and multiple cellular factors. Agonists that show higher potency to specific signaling pathways over others are known as “biased agonists” and have been shown to...

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Publicado en:Mol Pharmacol
Autores principales: Nivedha, Anita K., Tautermann, Christofer S., Bhattacharya, Supriyo, Lee, Sangbae, Casarosa, Paola, Kollak, Ines, Kiechle, Tobias, Vaidehi, Nagarajan
Formato: Artigo
Lenguaje:Inglês
Publicado: The American Society for Pharmacology and Experimental Therapeutics 2018
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5832328/
https://ncbi.nlm.nih.gov/pubmed/29367258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.117.110395
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