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Identifying Functional Hotspot Residues for Biased Ligand Design in G-Protein-Coupled Receptors
G-protein-coupled receptors (GPCRs) mediate multiple signaling pathways in the cell, depending on the agonist that activates the receptor and multiple cellular factors. Agonists that show higher potency to specific signaling pathways over others are known as “biased agonists” and have been shown to...
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| 發表在: | Mol Pharmacol |
|---|---|
| Main Authors: | , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
The American Society for Pharmacology and Experimental Therapeutics
2018
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5832328/ https://ncbi.nlm.nih.gov/pubmed/29367258 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.117.110395 |
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