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Engineering salt bridge networks between transmembrane helices confers thermostability in G-protein Coupled Receptors
Introduction of specific point mutations has been an effective strategy in enhancing the thermal stability in detergents that aid the purification of mono-dispersed G-protein coupled receptors (GPCRs). Our previous work showed that a specific residue position on transmembrane helix 6 (TM6) in class...
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| Pubblicato in: | J Chem Theory Comput |
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| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6549507/ https://ncbi.nlm.nih.gov/pubmed/30359017 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jctc.8b00602 |
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