Identifying Functional Hotspot Residues for Biased Ligand Design in G-Protein-Coupled Receptors

G-protein-coupled receptors (GPCRs) mediate multiple signaling pathways in the cell, depending on the agonist that activates the receptor and multiple cellular factors. Agonists that show higher potency to specific signaling pathways over others are known as “biased agonists” and have been shown to...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Mol Pharmacol
Prif Awduron: Nivedha, Anita K., Tautermann, Christofer S., Bhattacharya, Supriyo, Lee, Sangbae, Casarosa, Paola, Kollak, Ines, Kiechle, Tobias, Vaidehi, Nagarajan
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The American Society for Pharmacology and Experimental Therapeutics 2018
Pynciau:
Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5832328/
https://ncbi.nlm.nih.gov/pubmed/29367258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.117.110395
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