Rapid Computational Prediction of Thermostabilizing Mutations for G Protein-Coupled Receptors

[Image: see text] G protein-coupled receptors (GPCRs) are highly dynamic and often denature when extracted in detergents. Deriving thermostable mutants has been a successful strategy to stabilize GPCRs in detergents, but this process is experimentally tedious. We have developed a computational metho...

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Bibliografiske detaljer
Udgivet i:J Chem Theory Comput
Main Authors: Bhattacharya, Supriyo, Lee, Sangbae, Grisshammer, Reinhard, Tate, Christopher G., Vaidehi, Nagarajan
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2014
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4230369/
https://ncbi.nlm.nih.gov/pubmed/25400524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ct500616v
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