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How do mutations thermostabilize G protein-coupled receptors?

Structures of over 30 different G protein-coupled receptors (GPCRs) have advanced our understanding of cell signaling and provided a foundation for structure-guided drug design. This exciting progress required the development of three complimentary methods to facilitate GPCR crystallization, one of...

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Publicat a:Trends Pharmacol Sci
Autors principals: Vaidehi, Nagarajan, Grisshammer, Reinhard, Tate, Christopher G.
Format: Artigo
Idioma:Inglês
Publicat: 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4698185/
https://ncbi.nlm.nih.gov/pubmed/26547284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tips.2015.09.005
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