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How do mutations thermostabilize G protein-coupled receptors?
Structures of over 30 different G protein-coupled receptors (GPCRs) have advanced our understanding of cell signaling and provided a foundation for structure-guided drug design. This exciting progress required the development of three complimentary methods to facilitate GPCR crystallization, one of...
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| 發表在: | Trends Pharmacol Sci |
|---|---|
| Main Authors: | , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2015
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4698185/ https://ncbi.nlm.nih.gov/pubmed/26547284 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tips.2015.09.005 |
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