Machine Learning for Prioritization of Thermostabilizing Mutations for G-Protein Coupled Receptors

Although the three-dimensional structures of G-protein coupled receptors (GPCRs), the largest superfamily of drug targets, have enabled structure-based drug design, there are no structures available for 87% of GPCRs. This is due to the stiff challenge in purifying the inherently flexible GPCRs. Iden...

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Détails bibliographiques
Publié dans:Biophys J
Auteurs principaux: Muk, Sanychen, Ghosh, Soumadwip, Achuthan, Srisairam, Chen, Xiaomin, Yao, XiaoJie, Sandhu, Manbir, Griffor, Matthew C., Fennell, Kimberly F., Che, Ye, Shanmugasundaram, Veerabahu, Qiu, Xiayang, Tate, Christopher G., Vaidehi, Nagarajan
Format: Artigo
Langue:Inglês
Publié: The Biophysical Society 2019
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Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6895739/
https://ncbi.nlm.nih.gov/pubmed/31703801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2019.10.023
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