Variable G protein determinants of GPCR coupling selectivity

G protein-coupled receptors (GPCRs) activate four families of heterotrimeric G proteins, and individual receptors must select a subset of G proteins to produce appropriate cellular responses. Although the precise mechanisms of coupling selectivity are uncertain, the Gα subunit C terminus is widely b...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Okashah, Najeah, Wan, Qingwen, Ghosh, Soumadwip, Sandhu, Manbir, Inoue, Asuka, Vaidehi, Nagarajan, Lambert, Nevin A.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2019
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6575158/
https://ncbi.nlm.nih.gov/pubmed/31142646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1905993116
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