G12/13 is activated by acute tethered agonist exposure in the adhesion GPCR ADGRL3

The adhesion GPCR latrophilin 3 (ADGRL3) has been associated with increased risk of attention-deficit/hyperactivity disorder (ADHD) and substance use in human genetic studies. Knockdown in multiple species leads to hyperlocomotion and altered dopamine signaling. Thus, ADGRL3 is a potential target fo...

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Detalhes bibliográficos
Publicado no:Nat Chem Biol
Main Authors: Mathiasen, Signe, Palmisano, Tiago, Perry, Nicole A., Stoveken, Hannah M., Vizurraga, Alex, McEwen, Dyke P., Okashah, Najeah, Langenhan, Tobias, Inoue, Asuka, Lambert, Nevin A., Tall, Gregory G., Javitch, Jonathan A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7990041/
https://ncbi.nlm.nih.gov/pubmed/32778842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-020-0617-7
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