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How do mutations thermostabilize G protein-coupled receptors?
Structures of over 30 different G protein-coupled receptors (GPCRs) have advanced our understanding of cell signaling and provided a foundation for structure-guided drug design. This exciting progress required the development of three complimentary methods to facilitate GPCR crystallization, one of...
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| Vydáno v: | Trends Pharmacol Sci |
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| Hlavní autoři: | , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2015
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4698185/ https://ncbi.nlm.nih.gov/pubmed/26547284 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tips.2015.09.005 |
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